Can an AI safety framework work without new legislation? The besties unpack the White House accord pushing frontier model companies toward internal controls, external audits and board oversight. They debate superintelligence as an arms race, open-source AI, cyber defense, data centers and power, plus whether doomer narratives obscure strong growth, low unemployment and rising household income.

Can Spotify’s playbook help move healthcare from reactive treatment to prevention? Daniel Ek joins Jason and Friedberg to unpack Spotify’s climb to over 700 million active users, the licensing bets behind subscription music and his shift to Neko. They discuss longitudinal data, AI, wearables, clinician-led diagnostics and funding preventive care in the U.S.

Should AI companies face ordinary corporate liability? The besties debate responsible shipping versus global regulation, whether open-weight models will commoditize routine AI while frontier systems tackle harder problems, and how consumer agents could save time and money while disrupting app stores, subscriptions and opaque workflows. Plus, Trump and Obama on global AI control.